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Analysis of metal radioisotope impurities generated in [(18)O]H(2)O during the cyclotron production of fluorine-18.

Gillies JM, Najim N, Zweit J

Cancer Research-UK/UMIST Radiochemical Targeting and Imaging Group, Christie Hospital NHS Trust, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK. jgillies@picr.man.ac.uk

We show the separation of metal radioisotope impurities using capillary electrophoresis (CE). The methodology used is an improvement of existent protocols for separation of stable metal ions. Production of fluorine-18 using [(18)O]H(2)O-enriched water encased in a titanium target body results in the production of several metal radioisotope impurities. Optimisation of the conditions for CE separation of the metal radioisotope impurities incorporated the use of 6 mM 18-Crown-6 in combination with 12 mM glycolic acid as complexing agents within the running buffer (10 mM pyridine, pH 4.0). Using this optimised procedure, we were able to separate and detect a number of metal radioisotopes, including chromium, cobalt, manganese, vanadium and berillium, within the fM concentration range.

Published 8 February 2006 in Appl Radiat Isot, 64(4): 431-4.
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