Radioisotopes Research Today is a free monthly online journal that collates and summarizes the latest research about Radioisotopes, including details on radioimmunotherapy, radionuclides, procedures, hazards.

Ancestry of beagles in lifespan studies of radionuclide toxicity at the University of Utah.

Lloyd RD, Taylor GN, Miller SC, Bruenger FW, Jee WS

Department of Radiology, Radiobiology Division, University of Utah, 729 Arapeen Drive #2334, Salt Lake City, UT 84108-1218, USA. ray.lloyd@hsc.utah.edu

Analysis of the ancestry of the 1,262 lifespan beagles (LSB) entered into lifespan studies at the Radiobiology Division, University of Utah, beginning in 1952 and ending in 1980, indicated that about 97% of ancestor citations in the various pedigrees were of only 10 breeding animals (breeders) among breeders within the beagle colony. In turn, just 18 AKC-registered "champion" beagles from outside of this colony (founders) accounted for about 98% of all ancestor citations among founders for the LSB. We conclude from this study that the animals used in the lifespan radionuclide experiments can be considered to be somewhat genetically interrelated.

Published 12 May 2006 in Health Phys, 90(6): 580-2.
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